Combinatorial Chemistry: Powerful New Tool for Discovery and Product Development. 2nd Edition (Technical Insights)

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Combinatorial chemistry is a grid-based synthesis technique that can simultaneously generate tens, hundreds, or thousands of related compound collections that are called libraries. The process dramatically speeds materials discovery and product development. The leading application is drug discovery for the pharmaceuticals industry, but the use of combinatorial chemistry to develop advanced engineering materials is also generating intense interest.

Table of Contents

Combinatorial Chemistry, Executive SummaryExecutive SummaryOverviewScopeTechnology DescriptionOverviewKey DevelopmentsCombinatorial Chemistry, IntroductionThe Language of Combinatorial ChemistryWhat is Combinatorial Chemistry and CombiChem?Libraries and High-Throughput ScreeningThe Evolution of a TechnologyA Nobel BeginningCombiChem Against The Scientific MethodPromise and ProgressCombinatorial Chemistry, Technology DescriptionHow Does Combinatorial Chemistry Work?Solid-Phase SynthesisPolymer-Supported Reagents Microwave Heating Solution-Phase SynthesisTechnology ChallengesKnowledge-Based ApproachesMimeticsStructure-Based DesignLibrary FormatsAssay Technologies for High-Throughput ScreeningCombinatorial Chemistry, Market AnalysisMarkets for the TechnologyDrug Discovery: The Major Application for Combinatorial Chemistry Technologies Chemicals and Materials: Emerging ApplicationsPeripheral Markets: Systems/Software/ConsumablesMarket Drivers and ChallengesMarket DriversChallengesCombinatorial Chemistry, Key Companies: Listed Alphabetically by MarketR&D For Drug Discovery; Chemicals and Materials Industries3D Pharmaceuticals IncAffymax IncAlbany Molecular Research Inc.ArQule IncAvantium Technologies B.V.ChemBridge GroupDeltagen Inc.General Electric Corporate Research & Developmenthte AGPharmacopeia Inc. Symyx Technologies Inc. SynChem Inc.Uop LLC Systems; Supplies and Consumables For CombiChem ProcessesAccelrys Inc.Advanced ChemTech Inc.Affymetrix Inc. Berger Instruments Inc. / A Mettler-Toledo CompanyBio Trove Inc.Fluorous Technologies Inc. Johnson Matthey PLC; Catalysts and Chemicals DivisionLION bioscience AGLuminex CorporationMolecular Devices CorporationRobbins Scientific/ An Apogent CompanyTripos Inc.Combinatorial Chemistry, Research Highlights: Listed Alphabetically by Institution TypeR&D in Nonprofit LaboratoriesGenomics Institute of the Novartis Research FoundationNational Institute of Standards and Technology (NIST) Scripps Research Institute; Department of ChemistrySRI InternationalTorrey Pines Institute for Molecular StudiesUniversity-Based ResearchBoston UniversityCornell University; Department of Chemistry and Chemical BiologyNorthwestern University; Center for Nanofabrication and Molecular Self-AssemblyPurdue UniversityRensselaer Polytechnic InstituteSan Diego State UniversityUniversity of Alberta; Department of ChemistryUniversity of California-Berkeley; Department of ChemistryUniversity of California; Los AngelesUniversity of CambridgeCombinatorial Chemistry, Technical Insights' 2002 Science and Technology AwardsCombinatorial Chemistry AwardsAwards OverviewTechnology Innovation Award Category: Luminex Corp. Technology Leadership Award Category: Symyx Technologies Inc.Combinatorial Chemistry, References & Resources and GlossaryUseful URLsJournals and Other PeriodicalsGovernment WebsitesOther Useful URLsContact Information and GlossaryCompaniesCombiChem TermsProfessional OrganizationsCombinatorial Chemistry, Selected US PatentsSelected US PatentsUS Patents 2002Patents Assigned Before 2002

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