Combinatorial Chemistry: Powerful New Tool for Discovery and Product Development (Technical Insights)

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Table of Contents

Combinatorial Chemistry, Executive SummaryExecutive SummaryExecutive SummaryPerspective Perspective Challenges for Combinatorial Chemistry in Materials DevelopmentChallenges for Combinatorial Chemistry in Materials DevelopmentReturn on InvestmentReturn on InvestmentPharm/BiotechPharm/BiotechCombining Combinatorial Techniques with Structure-based Drug Design Combining Combinatorial Techniques with Structure-based Drug Design Materials DevelopmentMaterials DevelopmentProducts Already Headed to MarketProducts Already Headed to MarketSelecting Better Catalysts Using CombichemSelecting Better Catalysts Using CombichemHigh-Throughput Organic Synthesis (HTOS)High-Throughput Organic Synthesis (HTOS)GenomicsGenomicsSoftwareSoftwareCombinatorial Chemistry, IntroductionIntroductionIntroductionHow Does Combinatorial Chemistry Work? How Does Combinatorial Chemistry Work? The Processes of Combinatorial ChemistryThe Processes of Combinatorial ChemistryFive Advantages of Chemical Diversity Five Advantages of Chemical Diversity Combinatorial Chemistry, The TechnologyThe TechnologyThe TechnologyLibrary Generation and ScreeningLibrary Generation and ScreeningThe RoutineScreening Combinatorial Libraries MiniaturizationTarget Validation Managing Combinatorial Information Managing Combinatorial Information Computational ChemistryPharmaceutical Applications: Combinatorial Drug DesignCombining Combinatorial Techniques with Structure-based Drug Design Peptides and Oligonucleotides Organic Chemistry The Human GenomeMaterials Discovery: Beyond PharmaceuticalsMaterials Discovery: Beyond PharmaceuticalsEarly Work: Symyx and the University of California; Berkeley Deposition; Processing and Testing Examples: Ceramics; Glass and SAMsCombinatorial Chemistry, The MarketsA Revolution in ChemistryA Revolution in ChemistryMarket PressuresHigh-Throughput Organic Synthesis Is Good for MaterialsThe OpportunitiesSmall Companies Can CompeteProducts Already Headed to Market Advantages of Chemical Diversity Include Patent ProtectionSynergy: New Directions/New Partnerships Synergy: New Directions/New Partnerships Consortia Government Support for Combichem in Advanced Materials DevelopmentTools That Will Be Needed International Competition Materials Development: Market Needs and Limiting Factors Materials Development: Market Needs and Limiting Factors Technology Fusion Barriers to Commercialization Market Forecasts Range and Impact of Combinatorial ChemistryForecasts for Markets Affected by Combinatorial ChemistryCombinatorial Chemistry, Companies and Research groups3-Dimensional Pharmaceuticals: Combining Combinatorial Techniques with Structure-based Design 3-Dimensional Pharmaceuticals: Combining Combinatorial Techniques with Structure-based Design Acadia Pharmaceuticals: Treatments for Alzheimer’s DiseaseAcadia Pharmaceuticals: Treatments for Alzheimer’s DiseaseAffymax Research Institute and Glaxo Wellcome: TuberculosisAffymax Research Institute and Glaxo Wellcome: TuberculosisArgonex: Cancer ImmunotherapyArgonex: Cancer ImmunotherapyAxiom: New Screening Technologies—Conditional Changes; MiniaturizationAxiom: New Screening Technologies—Conditional Changes; MiniaturizationAxys Pharmaceuticals: Protease Inhibitors for Asthma and Other DiseasesAxys Pharmaceuticals: Protease Inhibitors for Asthma and Other DiseasesThe University of California; Berkeley: Combinatorial Library Yields Blue LightThe University of California; Berkeley: Combinatorial Library Yields Blue LightCalTech: Building a Protein CalTech: Building a Protein CombiChem Inc. and Novartis AG: Crop ProtectionCombiChem Inc. and Novartis AG: Crop ProtectionCombiChem Inc.: Collaborating with Japan’s Teijin on G-Protein AntagonistsCombiChem Inc.: Collaborating with Japan’s Teijin on G-Protein AntagonistsCubist Pharmaceuticals and Neurogen: Fighting Antibiotic ResistanceCubist Pharmaceuticals and Neurogen: Fighting Antibiotic ResistanceDyax Corp.: Phage Display TechnologyDyax Corp.: Phage Display TechnologyHistory Product and Technology Patents Financing Opportunities EnzyMed: Discovering Biologically Active Molecules Produced Through Combinatorial BiocatalysisEnzyMed: Discovering Biologically Active Molecules Produced Through Combinatorial BiocatalysisExelixis: Genomics Provides Tools to Find New Pesticides Exelixis: Genomics Provides Tools to Find New Pesticides Harvard University: Institute for Chemistry and Cell BiologyHarvard University: Institute for Chemistry and Cell BiologyIllinois at Urbana-Champaign: NMR Analysis on a Chip Illinois at Urbana-Champaign: NMR Analysis on a Chip Isis Pharmaceuticals and HNC Software: DARPA Funding Against Biological WarfareIsis Pharmaceuticals and HNC Software: DARPA Funding Against Biological WarfareIxsys: Random Libraries of DNA; RNA; Peptides and ProteinsIxsys: Random Libraries of DNA; RNA; Peptides and ProteinsLawrence Berkeley Labs (LBL): Building Libraries of Electronic MaterialsLawrence Berkeley Labs (LBL): Building Libraries of Electronic MaterialsMolecular Simulations: CombiChem ConsortiumMolecular Simulations: CombiChem ConsortiumSUNY-Buffalo: Genetic Algorithms Yield Selection of the Fittest Through Dynamic Combinatorial Chemistry SUNY-Buffalo: Genetic Algorithms Yield Selection of the Fittest Through Dynamic Combinatorial Chemistry NeXstar Pharmaceuticals and Glaxo Wellcome: GenomicsNeXstar Pharmaceuticals and Glaxo Wellcome: GenomicsNorth Carolina at Chapel Hill: IR Thermography for Catalytic ScreeningNorth Carolina at Chapel Hill: IR Thermography for Catalytic ScreeningNovartis AG: Big Functional Genomics in the United StatesNovartis AG: Big Functional Genomics in the United StatesOSI Pharmaceuticals and Hoechst Marion Roussel: Fighting AnemiaOSI Pharmaceuticals and Hoechst Marion Roussel: Fighting AnemiaPennsylvania State University and the Illinois Institute of Technology: Screening for Anode CatalysisPennsylvania State University and the Illinois Institute of Technology: Screening for Anode CatalysisPennsylvania State University: Catalyst Surface StructurePennsylvania State University: Catalyst Surface StructurePharmacopeia: Drug Leads for Malaria and InflammationPharmacopeia: Drug Leads for Malaria and InflammationPhotosynthetic Harvest: “Milking” Green Plants for Valuable Natural Products Photosynthetic Harvest: “Milking” Green Plants for Valuable Natural Products Proteome Systems Limited (PSL) and Dow AgroSciences: A Research Agreement in ProteomicsProteome Systems Limited (PSL) and Dow AgroSciences: A Research Agreement in ProteomicsReceptor Technologies: Screening Hundreds of Receptor Genes at OnceReceptor Technologies: Screening Hundreds of Receptor Genes at OnceRepligen: Compound Blocks Angiogenesis FactorsRepligen: Compound Blocks Angiogenesis FactorsRh’ne-Poulenc Rorer and Cambridge University: Targeting Incurable DiseasesRh’ne-Poulenc Rorer and Cambridge University: Targeting Incurable DiseasesRibozyme Pharmaceuticals: Ribozymes That Treat Hepatitis C and HIV and That Block AngiogenesisRibozyme Pharmaceuticals: Ribozymes That Treat Hepatitis C and HIV and That Block AngiogenesisScripps Research Institute: Picking the Right Catalytic Antibody from a Combinatorial LibraryScripps Research Institute: Picking the Right Catalytic Antibody from a Combinatorial LibraryScripps Research Institute and the University of California at San Diego: Detecting Any Molecule That Binds TightlyScripps Research Institute and the University of California at San Diego: Detecting Any Molecule That Binds TightlyScriptgen Pharmaceuticals and Eli Lilly: Screening for Drug LeadsScriptgen Pharmaceuticals and Eli Lilly: Screening for Drug LeadsCompetition for Symyx: Scylla Chemical Does Combichem for MaterialsCompetition for Symyx: Scylla Chemical Does Combichem for MaterialsScylla’s TechnologyPartnering Opportunities with ScyllaSibia Neurosciences: Resins Showing That High-Throughput Organic Synthesis is Good for MaterialsSibia Neurosciences: Resins Showing That High-Throughput Organic Synthesis is Good for MaterialsSymyx Technologies: Ahead of the Pack in Materials DevelopmentSymyx Technologies: Ahead of the Pack in Materials DevelopmentThe Symyx Strategy Technology Development at SymyxMaterials Discovery; Optimization Symyx Corporate CollaborationsVertex Pharmaceuticals: Assaying Smaller Libraries and Finding Likely Drug Molecules Vertex Pharmaceuticals: Assaying Smaller Libraries and Finding Likely Drug Molecules Xenova: New Compounds from Natural ProductsXenova: New Compounds from Natural ProductsArQule: Complex Natural Compound Analogs; Protease Inhibitors; BioseparationsArQule: Complex Natural Compound Analogs; Protease Inhibitors; BioseparationsCombinatorial Chemistry, Combinatorial Chemical CompaniesCompany DetailsCompany DetailsCombinatorial Chemistry, Software CompaniesSoftware CompaniesSoftware CompaniesCombinatorial Chemistry, Academic Research groupsAcademic Research groupsAcademic Research groupsCombinatorial Chemistry, Key Contacts Within Combinatorial ChemistryKey Contacts Within Combinatorial ChemistryKey Contacts Within Combinatorial ChemistryCombinatorial Chemistry, Selected US PatentsSelected US PatentsSelected US PatentsCombinatorial Chemistry, Useful Website URLsUseful Website URLsUseful Website URLs




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