The term hybrid imaging essentially refers to hardware-based image fusion where two different imaging modalities are combined in a single equipment. As image fusion through the hardware approach offers several advantages over software-based image fusion, such as accuracy of image co-registration and ease of image fusion through a single scan session, to name a few, hybrid scanners such as positron emission tomography-computed tomography (PET-CT) were introduced in 2001, followed by the introduction of single photon emission computed tomography-computed tomography (SPECT-CT) hybrids in 2003. These two modalities are established in the market today, with PET-CT being the standard of care in oncology and SPECT-CT an upcoming hybrid modality currently being used mainly for cardiac scans. Presently, attempts are also being made to bring out hybrid imaging platforms, such as MRI-Optical imaging CT-optical imaging, and so on. These modalities are expected to have significant penetration potential mainly in clinical segments, such as oncology, cardiology, and neurology.