Lab-on-a-Chip: The Revolution in Portable Instrumentation - 3rd Edition (Technical Insights)

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Table of Contents

Lab-on-a-Chip: The Revolution in Portable Instrumentation - 3rd Edition (Technical Insights), Executive SummaryExecutive SummaryExecutive SummaryHistoryHistoryMicro-Total Analytical Systems vs. Limited Function LOCsMicro-Total Analytical Systems vs. Limited Function LOCsGovernment SupportGovernment SupportBusiness Climate for LOCsBusiness Climate for LOCsBarriers to Development and CommercializationBarriers to Development and CommercializationSynthesis LOCsSynthesis LOCsMedical DiagnosticsMedical DiagnosticsDNA Microchips (“Biochips”)DNA Microchips (“Biochips”)Environmental TestingEnvironmental TestingTrends in LOC DevelopmentTrends in LOC DevelopmentMicrofluidics vs. MicroarraysMicrofluidics vs. MicroarraysLab-on-a-Chip: The Revolution in Portable Instrumentation - 3rd Edition (Technical Insights), ImpactTrends in LOC DevelopmentTrends in LOC DevelopmentThe Challenge of LOCsThe Challenge of LOCsAdvantages of LOCsAdvantages of LOCsWhere Do LOCs Fit into Analytical Markets?Where Do LOCs Fit into Analytical Markets?Lab-on-a-Chip: The Revolution in Portable Instrumentation - 3rd Edition (Technical Insights), Barriers to commercializationBarriers to commercializationBarriers to commercializationMechanical and Process Issues for LOCsMechanical and Process Issues for LOCsPerformance RequirementsPerformance RequirementsDisadvantages and Barriers to CommercializationLOCsSensorsLab-on-a-Chip: The Revolution in Portable Instrumentation - 3rd Edition (Technical Insights), Comments and Ideas from Experts in the fieldComments and Ideas from Experts in the fieldComments and Ideas from Experts in the fieldLab-on-a-Chip: The Revolution in Portable Instrumentation - 3rd Edition (Technical Insights), Markets; Impact and Business Climate for LOCsMarkets; Impact and Business Climate for LOCsMarkets; Impact and Business Climate for LOCsMedical DiagnosticsMedical DiagnosticsChemical Analysis InstrumentationChemical Analysis InstrumentationSensorsATP Focused Program in Nano- and MEMS Technologies for Chemical and Biosensors BiosensorsOther MarketsDNA MicrochipsEnvironmental TestingAntibody-Based AnalysisMEMS and LOCsLOC Business ClimateLOC Business ClimateLOC Technology Redefines ItselfAnalytical Arrays on “Chips”Array LOCs and InstrumentationHow to Expoit LOCsHow to Expoit LOCsLab-on-a-Chip: The Revolution in Portable Instrumentation - 3rd Edition (Technical Insights), LOC TechnologiesµTAS: Complete Chemistry Labs-on-a-ChipµTAS: Complete Chemistry Labs-on-a-ChipFluid Handling; Mixing; Reacting and DetectionFluid Handling; Mixing; Reacting and DetectionElectrophoresis LOCs—Biochemical AnalysisThe Oak Ridge National Laboratories LOCThe University of Alberta LOCDNA Analysis and Polymerase Chain Reaction on a Silicon MicrostructureDNA Analysis and Polymerase Chain Reaction on a Silicon MicrostructureMass Spectrometer-on-a-ChipMass Spectrometer-on-a-ChipCaliper Technologies Corp.Caliper Technologies Corp.TechnologySpecimen HandlingAnnular Column Chromatography with Built-in Optical AnalysisAnnular Column Chromatography with Built-in Optical AnalysisAclara Biosciences Inc. (formerly Soane Biosciences): Microfluidics and Capillary ElectrophoresisAclara Biosciences Inc. (formerly Soane Biosciences): Microfluidics and Capillary ElectrophoresisTechnologyManagement and AdvisorsTexas Instruments Inc.Texas Instruments Inc.Blood Gas Analyzers-on-a-ChipBlood Gas Analyzers-on-a-ChipSperm Testing with Microfabricated Silicon MicrochannelsSperm Testing with Microfabricated Silicon MicrochannelsMicrophysiometry—Intracellular SensingMicrophysiometry—Intracellular SensingMolecular Devices Corp.: Silicon Microphysiometer Reveals Cell MetabolismUniversity of Michigan: PEBBLEs Monitor Intracellular Ion ConcentrationsUniversity of California; San Diego: Live Molecules on the MoveMemorial Sloan-Kettering: pH-Sensitive GFPs Mark Subcellular CompartmentsMotion SensingMilli Sensor Systems and Actuators Inc.: MillimachiningUniversity of Michigan: MEMS Resonator for LOC Gyroscopes; Internal ClocksNanogen: Microfabricated Lab Finds Germs Nanogen: Microfabricated Lab Finds Germs Georgia Tech: Microneedle Arrays Deliver DrugsGeorgia Tech: Microneedle Arrays Deliver DrugsNSF: “XYZ-on-a-Chip” Initiative Seeks Novel Applications for Microelectronics NSF: “XYZ-on-a-Chip” Initiative Seeks Novel Applications for Microelectronics Lab-on-a-Chip: The Revolution in Portable Instrumentation - 3rd Edition (Technical Insights), Synthesis LOCsSynthesis LOCsSynthesis LOCsModular Miniaturized Chemical Systems ReactorsModular Miniaturized Chemical Systems ReactorsUniversity of Twente: A Miniature Chemical SystemIrori Quantum Microchemistry: Microchip-Based Combinatorial Chemistry KitOrchid Biocomputer and David Sarnoff Laboratory—Analysis and Synthesis-on-a-ChipOrchid Biocomputer and David Sarnoff Laboratory—Analysis and Synthesis-on-a-ChipCombinatorial Synthesis for Drug Screening and Materials DiscoveryCombinatorial Synthesis for Drug Screening and Materials DiscoveryPeptidesPharmaceutical ChemistryMaterials Discovery Products Already Headed to MarketUniversity of South Australia: MicrobioreactorUniversity of South Australia: MicrobioreactorBattelle Pacific Northwest Laboratory: Microscale CombusterBattelle Pacific Northwest Laboratory: Microscale CombusterUniversity of Texas MicroreactorUniversity of Texas MicroreactorSymyx; University of California; Berkeley and Lawrence Berkeley Labs: Combinatorial Materials SynthesisEarly WorkDeposition; Processing and Testing The Symyx Strategy Technology Development at SymyxLab-on-a-Chip: The Revolution in Portable Instrumentation - 3rd Edition (Technical Insights), DNA MicroanalyzersDNA MicroanalyzersDNA MicroanalyzersDNA Analysis-on-a-ChipDNA Analysis-on-a-ChipAffymetrix: Combinatorial DNA AnalysisAffymetrix: Combinatorial DNA AnalysisTechnologyThe Chip’s Unit OperationsPatent Battles: Affymetrix; Incyte; Synteni; Hyseq and OthersID Biomedical Corp.: Cycling Probe Technology Amplifies Like PCRID Biomedical Corp.: Cycling Probe Technology Amplifies Like PCRCuragen Inc.: DNA Separation by WeightCuragen Inc: DNA Separation by WeightUniversity of Pennsylvania: Ligase Chain Reaction AnalysisUniversity of Pennsylvania: Ligase Chain Reaction AnalysisGenometrix Inc.Genometrix Inc.TechnologyStrategic AlliancesManagement and AdvisorsIntellectual PropertyNanogen Inc.Nanogen Inc.TechnologyWhat a Bioassay Chip Can DoAdvantagesManagement and AdvisorsGenosensor ConsortiumGenosensor ConsortiumBeckman Instruments Inc.Beckman Instruments Inc.Whitehead Institute: High-Speed DNA-Sequencing Micromachines Whitehead Institute: High-Speed DNA-Sequencing Micromachines University of Michigan: Analyze DNA with Nanoliter Lab-on-a-Chip University of Michigan: Analyze DNA with Nanoliter Lab-on-a-Chip University of California; Berkeley: Radial Capillary Array Electrophoresis SystemUniversity of California; Berkeley: Radial Capillary Array Electrophoresis SystemMotorola; Packard and Argonne: Find One Genetic Variation Among Three Billion DNA Bases in a Matter of Minutes Motorola; Packard and Argonne: Find One Genetic Variation Among Three Billion DNA Bases in a Matter of Minutes Molecular Dynamics: Fluorescence-Based; Capillary Gel Electrophoresis SequencingMolecular Dynamics: Fluorescence-Based; Capillary Gel Electrophoresis SequencingLifecodes: Human Identity Testing and HLA Typing Lifecodes: Human Identity Testing and HLA Typing GeneTrace Systems: Automated DNA Sequencing with Time-of-Flight Mass Spectrometry Analyzing Gene Expression or Copy-Number-on-a-ChipNEN Life ScienceIncyte Pharmaceuticals Inc. Vysis: Genomic Array System for Detecting Abnormal Gene Numbers Polymerase Chain Reaction (PCR)-on-a-ChipPolymerase Chain Reaction (PCR)-on-a-ChipCaliper TechnologiesImperial College: Micromachined Chemical Amplifier Speeds AnalysisOak Ridge National Laboratories (ORNL)Cepheid Inc.Hebrew University - JerusalemAffymetrix and Roche Molecular Systems Inc.Codevelopment OpportunitiesDNA Chips for Agricultural StudiesDNA Chips for Agricultural StudiesLab-on-a-Chip: The Revolution in Portable Instrumentation - 3rd Edition (Technical Insights), Enabling TechnologiesEnabling TechnologiesEnabling TechnologiesDetection-on-a-ChipDetection-on-a-ChipMicrophotonics Fiber-Optic SensorsAdvanced Microbotics Corp: Chemical Detection Based on Molecular RecognitionOptical Addressing of LOCsSandia National Laboratories: Pattern Recognition System for Sensors-on-a-ChipSandia National Laboratories: Differential Flow Rates for Chemical-Sensor Lab-on-a-ChipSandia National Laboratories: Tiny Acoustic Wave Sensors Will Detect Minute Traces of Dangerous Chemicals Johns Hopkins University: Visual Sensor-on-a-Chip Cyrano Sciences Inc. and Hewlett-Packard: Differential Resistance Allows Sensors to Detect Odors; Respiratory Infection or Bad Breath BacteriaUniversity of Texas at Austin: Electronic Tongue Attached to Camera-on-a-Chip Connected to a ComputerBerkeley MicroInstruments: Microsensor Measures Liquid Viscosity MicrofluidicsMicrofluidicsMIT: Microfabricated Fused Flow ChambersMicropumpsFraunhofer Institute: Meandering Flow Channels with Access PortsFraunhofer Institute: Micromechanical Pneumatic ValveUniversity of California; Davis: Surfactant Redox to Move Fluids Gamera’s Bioscience Corp.: Turn CD Player into a Bioanalysis DeviceUniversity of Wales at Bangor: Electrokinetic Analysis of CellsPrinceton University: Continuous Flow Mixer Gives You Fast Mixing Without Turbulence MicroelectronicsHarvard University: Refrigerator-on-a-ChipOak Ridge National Laboratories: Photosynthesis Can Power NanomachinesBrigham Young University: Get Battery down to MEMS ScaleUniversity of California; San Diego: DNA Glues Optoelectronic ComponentsTechnion: DNA Helps Connect NanoelectronicsBiosensorsBiosensorsWhat Is Surface Plasmon Resonance?Biointegrated Circuits as Chemical SensorsImmunoassays Integrated with OpticsVirginia Tech: Laser Beam Bombardment Produces Pathogen Detection University of Maryland: Dual Emitters Allow Biosensors To Act as Their Own Internal StandardImmunosensorsFabrication TechnologiesPurdue University: Porous Silicon Lights Way for New Analytical Devices Stanford University: Nanotube Circuits-on-a-Chip Cornell University: Artificial Gels Could Speed DNA Sequencing Rockefeller University: Build Biochips a Molecule at a Time with Optical TweezersLithographyLab-on-a-Chip: The Revolution in Portable Instrumentation - 3rd Edition (Technical Insights), MEMS: MICROELECTROMECHANICAL SYSTEMSIntroductionIntroductionAPPLICATIONS OF MEMS TO LOCSMEMS MICROGEARS; MICROPUMPS; VALVES; ACTUATORS; MIRRORS; AND CLOCKS FOR LOCSSANDIA NATIONAL LABORATORIES: A SILICON MICROMOTORLOUISIANA STATE UNIVERSITY: MICROPUMP HAS NO MOVING PARTSLUCENT TECHNOLOGIES: MICROMECHANICAL MIRRORS ROUTE LIGHT SIGNALSSANDIA: MEMS CLOCK TIMES SYSTEM-ON-A-CHIPMEMS-ENABLED ANALYSIS AND SENSORSOAK RIDGE NATIONAL LABORATORIES: MICROCANTILEVERS PUT SENSOR ARRAY ON CHIPUNIVERSITY OF CALIFORNIA; BERKELEY: CHEAP MEMS LASER SCANNER IS COMINGUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN: MEMS NMR ANALYSIS-ON-A-CHIPLOS ALAMOS AND IBM: SIMULATE FLUID FLOWS IN MEMSMIT: IMPLANTABLE MICROCHIP RELEASES ON DEMANDLab-on-a-Chip: The Revolution in Portable Instrumentation - 3rd Edition (Technical Insights), Organizations Involved in MEMs and Microfluidics R&DOrganizations Involved in MEMs and Microfluidics R&DOrganizations Involved in MEMs and Microfluidics R&DMCNC: MUMPs ProgramMCNC: MUMPs ProgramNIST/USC: MOSISNIST/USC: MOSISAnalog Devices Inc.Analog Devices Inc.DARPA’s Microfluidic Molecular Systems ProgramDARPA’s Microfluidic Molecular Systems ProgramEIC Laboratories Inc.EIC Laboratories Inc.David Sarnoff Research CenterDavid Sarnoff Research CenterLawrence Livermore National Laboratory - Microtechnology CenterLawrence Livermore National Laboratory - Microtechnology CenterProfiles of Other MEMS OrganizationsAlberta Microelectronics Center (Canada)Berkeley Sensors and Actuators CenterCase Western Reserve UniversityThe University of Durham (UK)EG&G IC SensorsMassachusetts Institute of TechnologyUniversity of MichiganVTT Electronics (Finland)Lab-on-a-Chip: The Revolution in Portable Instrumentation - 3rd Edition (Technical Insights), Polymers and Emerging LOC OpportunitiesPolymers and Emerging LOC OpportunitiesPolymers and Emerging LOC OpportunitiesPlastic-Coated Microfluidic DevicesPlastic-Coated Microfluidic DevicesNational Institute of Standards and Technology (NIST)Microfabrications and IntegrationMicromolding in Capillaries (MIMIC)Pulsed Laser DepositionGlass-Glass Microbonding TechniqueGlass-Silicon BondingLab-on-a-Chip: The Revolution in Portable Instrumentation - 3rd Edition (Technical Insights), Appendix A: Contact InformationAppendix A: Contact InformationAppendix A: Contact InformationLab-on-a-Chip: The Revolution in Portable Instrumentation - 3rd Edition (Technical Insights), Appendix B: Selected PatentsAppendix B: Selected PatentsAppendix B: Selected PatentsLab-on-a-Chip: The Revolution in Portable Instrumentation - 3rd Edition (Technical Insights), Appendix C: ReadingsAppendix C: ReadingsAppendix C: ReadingsLab-on-a-Chip: The Revolution in Portable Instrumentation - 3rd Edition (Technical Insights), Appendix D: Useful Website URLsAppendix D: Useful Website URLsAppendix D: Useful Website URLsLOCs - GeneralLOCs - GeneralMEMSMEMSSensors Sensors BioChips; DNA Analysis; MicroarraysBioChips; DNA Analysis; MicroarraysµTAS (Micro-Total Analysis Systems)µTAS (Micro-Total Analysis Systems)




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