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This edition of Drug Discovery Alert depicts life sciences trends across novel drug delivery systems (NDDS). The physiochemical properties of some powerful novel therapeutics such as poor solubility and poor permeation can at times leads to mistargeting at the active site. This concern generates a barrier for therapeutic efficacy. Various nanoformulation strategies and drug delivery systems have been designed for overcoming this barrier, and to providing uniform drug targeting at the active site in the desired concentration and with improved therapeutic efficacy. Such strategies constitute what has been coined as novel drug delivery systems (NDDS). NDDS comprises nanoparticles, emulsion-based formulations, liposomes, phytosomes, photosomes, microspheres, and other topical formulations aiming to enhance the bioavailability of many therapeutic agents. In this issue, we have highlighted some novel applications of NDDS-based approaches for enhancing the therapeutic potential of several drugs, thereby enabling them to exhibit their biological activities. The corresponding patent scenario is depicted, along with the industry interactions around this technology trend..The Drug Discovery Alert reports and analyzes about the latest developments in drug discovery and therapeutics, thereby providing an opportunity to acquire strategic insights into crucial developments in this industry domain. Technologies profiled include those used for biomarker and target discovery such as high throughput screening, signal transduction, micro array, RNAi, metabolomics, toxicogenomics, biosensors and nanotechnology. In addition to these, a fair focus shall be dedicated to the latest trends in therapeutic approaches across a diversity of diseases including infectious, genetic, metabolic, neurological, cardiac, and autoimmune disorders. The Health and Wellness cluster tracks developments in a myriad of areas including genetic engineering, regenerative medicine, drug discovery and development, nanomedicine, nutrition, cosmetic procedures, pain and disease management and therapies, drug delivery, personalized medicine, and smart healthcare.Keywords: novel drug delivery systems, NDDS, drug targeting, therapeutic efficacy, nanoparticles, liposomes, phytosomes, photosomes, microspheres, nanoformulations, bioavailability enhancers, natural monodisperse phytoglycogen nanomaterials, microneedle pill
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