This deliverable provides insights on the many macro issues facing the pharma and biotech industry. The industry is currently in a state of transition and is faced with a myraid of challenges including the dreaded patent cliff. This research service presents a total market forecast, market share analysis by leading companies, top therapeutic classes by spend, major patent expirations and their implications, biosimilar challenges and opportunities, merger and acquisition overview and analysis, a look at changing business models and market trends, opportunities and challenges.