Proteomics: Promising Research/Potential Applications/and New Developments (Technical Insights)

 


To achieve the promise presented by mapping the human genome, we must strive to understand what is happening in a cell beyond the DNA sequence of a given gene. As a result scientists are performing extensive study of proteins. While genes carry the blueprints for life, proteins perform the vital functions necessary for life to exist. This report provides in-depth coverage of proteomic research and identifies the most promising developments and potential applications.
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Table of Contents

Proteomics: Promising Research/Potential Applications/and New Developments (Technical Insights), Executive SummaryGenes and ProteinsGenomics and ProteomicsBioinformatics Analysis of Proteomics DataPharmaceutical ApplicationsProteomics TechniquesProteomics Analysis2-D Gel ElectrophoresisSpectrometryPhage DisplayYeast 2-Hybrid SystemLab on a Chip (LOC) TechnologiesMicrofluidic LOCsBiochips and MicroarraysAdditional Proteomics Technologies: Bioinformatics; Functional Genomics; and Structural GenomicsProteomics: Promising Research/Potential Applications/and New Developments (Technical Insights), IntroductionIntroductionIntroductionProteomic MethodsBioinformatics Analysis of Proteomics DataBioinformatics Analysis of Proteomics DataStudying Proteins Versus Studying GenesPharmaceutical ApplicationsIdentifying Novel TherapeuticsDrug DiscoveryProteomics TechniquesProteomics Techniques2-D Gel ElectrophoresisSpectrometryPhage Display; Yeast 2-Hybrid SystemPhage DisplayYeast 2-Hybrid SystemLab-on-a-Chip (LOC) TechnologiesLab on a Chip (LOC) TechnologiesMicrofluidic LOCsBiochips and MicroarraysProteomics: Promising Research/Potential Applications/and New Developments (Technical Insights), New Enabling TechnologiesCal Tech's Beckman Institute: MRI Shows Gene Expression Anywhere in OrganismCal Tech's Beckman Institute: MRI Shows Gene Expression Anywhere in OrganismGeneProt: New Method Automates Mass SpecGeneProt: New Method Automates Mass SpecUniversity of Michigan: New Protein Separation Faster Than 2-D GelsUniversity of Michigan: New Protein Separation Faster Than 2-D GelsCytogen: Ligand Target CloningCytogen: Ligand Target CloningHybrigenicsWith Institut Pasteur: Hybrigenics Named Exclusive Licensee To Protein-Interactions PatentBacterial Two-Hybrid System Better Than YeastProtein Interactions Mapped out in H. pyloriMap of Protein Interactions Between HIV and Host CellsWith Lynx Therapeutics: ObesityWith XTL: Hepatitis C Virus (HCV) TherapeuticsLexicon: Gene-Trapping Technique Detects Rare ProteinsLexicon: Gene-Trapping Technique Detects Rare ProteinsRheoGene: Multiplexed Gene -Regulation Technology for Studying Complex Gene InteractionsRheoGene: Multiplexed Gene -Regulation Technology for Studying Complex Gene InteractionsHTS Biosystems: Surface Plasmon ResonanceHTS Biosystems: Surface Plasmon ResonanceWith Dyax Corp: Phage Display for Antibody ChipsWith Boston Probes and Applied Biosystems: Peptide Nucleic Acid (PNA) TechnologyMitsubishi Chemical: Purchase and Distribution AgreementRosemount: Mass Spectrometer on a ChipRosemount: Mass Spectrometer on a ChipCaliper Technologies: Microfluidics and Lab on a ChipWith Structural Genomix: High-Throughput Protein AnalysisConflict with Aclara ResolvedJohns Hopkins; NYU; Mount Sinai: Bisubstrates Squelch Errant EnzymesJohns Hopkins; NYU; Mount Sinai: Bisubstrates Squelch Errant EnzymesSUNY and University of Tokyo: Making Novel Proteins Using a 21st-Century Amino AcidSUNY and University of Tokyo: Making Novel Proteins Using a 21st-Century Amino AcidVanderbilt University: New Technology Expands Molecular Photography OptionsVanderbilt University: New Technology Expands Molecular Photography OptionsVirginia Tech: Dried Cells; Tissues Could Solve Biological Materials Storage; Transport ProblemsVirginia Tech: Dried Cells; Tissues Could Solve Biological Materials Storage; Transport ProblemsWhitehead Institute and Mass General: Interaction Sequence TagsWhitehead Institute and Mass General: Interaction Sequence TagsPhylosAlternative to Phage DisplayProtein-Expression ChipAntibody-Like Protein Scaffolds for Cancer TreatmentHarvard University: Protein Chips Probe Protein FunctionHarvard University: Protein Chips Probe Protein FunctionUniversity of Pennsylvania: IDAT Detects Proteins at Unprecedented ResolutionUniversity of Pennsylvania: IDAT Detects Proteins at Unprecedented ResolutionCaliper and Structural Genomix High Throughput Proteomics LabchipCaliper and Structural Genomix High Throughput Proteomics LabchipDetection on a Chip: MicrophotonicsDetection on a Chip: MicrophotonicsNorthwestern University: Microphotonic ResonatorNanogen: Photonic Energy TransferIllumina: Fiberoptic Arrays House 250000 Discrete Sensors on Pinhead-Sized ProbeHoffman-La Roche: Bacteria Chips to Study AntibioticsHoffman-La Roche: Bacteria Chips to Study AntibioticsEMBL Begets Cellzome: TAP Method Yields Low-Abundance Proteins and Multicomponent ComplexesEMBL Begets Cellzome: TAP Method Yields Low-Abundance Proteins and Multicomponent ComplexesNEN Life Science: Analyzing Gene Expression or Copy Number on a ChipNEN Life Science: Analyzing Gene Expression or Copy Number on a ChipProteomics: Promising Research/Potential Applications/and New Developments (Technical Insights), Functional GenomicsFunctional GenomicsFunctional GenomicsHuman Genome Sciences Wins AIDS-Receptor Drug Target PatentHuman Genome Sciences Wins AIDS-Receptor Drug Target PatentAgritope: Functional Genomics for PlantsAgritope: Functional Genomics for PlantsDevgen NV: Belgian Firm Focuses on Functional GenomicsDevgen NV: Belgian Firm Focuses on Functional GenomicsParadigm Genetics: 150 Plant Gene Functions per WeekParadigm Genetics: 150 Plant Gene Functions per WeekCuraGen: Functional Genomics for TherapeuticsCuraGen: Functional Genomics for TherapeuticsProtein Interaction Map of Yeast; Fruit FlyWith Cor Tx: Cardiovascular DrugsRigel and Pfizer: AllergiesRigel and Pfizer: AllergiesDOE Grants Focus on Microbial Waste Remediation; Carbon Management; Energy Production; BiotechDOE Grants Focus on Microbial Waste Remediation; Carbon Management; Energy Production; BiotechGenset: Protein Takes Fat off Obese MiceGenset: Protein Takes Fat off Obese MiceMDS Proteomics Links with Zyomyx; IBMMDS Proteomics Links with Zyomyx; IBMArqule and Acadia: G-Protein-Receptors as Drug TargetsArqule and Acadia: G-Protein-Receptors as Drug TargetsNeotherapeutics: Therapies for Neurodegenerative DiseaseNeotherapeutics: Therapies for Neurodegenerative DiseaseNeogene Technologies: G-Protein-Coupled ReceptorsNeogene Technologies: G-Protein-Coupled ReceptorsCereon Genomics: Arabidopsis Data Released through Public-Private PartnershipCereon Genomics: Arabidopsis Data Released through Public-Private PartnershipExelixis: Functional Genomics in DrosophilaExelixis: Functional Genomics in DrosophilaAurora Patents Gene Tagging SystemAurora Patents Gene Tagging SystemUPenn: Pure-Blood MicrochipsUPenn: Pure-Blood MicrochipsCadus Pharmaceutical: Orphan Receptors and G-ProteinCadus Pharmaceutical: Orphan Receptors and G-ProteinMycota Biosciences: Functional Genomics in Fungus to Find Drug TargetsMycota Biosciences: Functional Genomics in Fungus to Find Drug TargetsMendel Biotech: Technology Makes Plants More WeatherproofMendel Biotech: Technology Makes Plants More WeatherproofHyseq Protein May Reduce Blood ClottingHyseq Protein May Reduce Blood ClottingProteomics: Promising Research/Potential Applications/and New Developments (Technical Insights), Structural GenomicsStructural GenomicsStructural GenomicsProtein FoldingProtein FoldingNIGMS: $150 Million for Multicenter Protein Structure InitiativeNIGMS: $150 Million for Multicenter Protein Structure InitiativeNew York Structural Genomics Research ConsortiumNortheast Structural Genomics ConsortiumThe Midwest Center for Structural GenomicsThe Structural Genomic CenterNortheast Structural Genomics ConsortiumTB Structural Genomics ConsortiumSoutheast Collaboratory for Structural GenomicsJoint Center for Structural GenomicsUniversity of Washington: Computational Method may Hold Key to Predicting Protein FoldingUniversity of Washington: Computational Method may Hold Key to Predicting Protein FoldingBerkeley Lab's Advanced Light Source Accelerates X-Ray CrystallographyBerkeley Lab's Advanced Light Source Accelerates X-Ray CrystallographyUniversity of California-Santa Cruz: New Images Reveal the Workings of Cellular Protein FactoriesUniversity of California-Santa Cruz: New Images Reveal the Workings of Cellular Protein FactoriesKeio University; Teikyo University Biotechnology Center: Snapshots of a Molecular MotorKeio University; Teikyo University Biotechnology Center: Snapshots of a Molecular MotorIntegrative Proteomics: X-Ray; NMR; Mass Spec for Target IDIntegrative Proteomics: X-Ray; NMR; Mass Spec for Target IDWistar Institute: X-Ray Structure Reveals Similarities in Molecules Linked to CancersWistar Institute: X-Ray Structure Reveals Similarities in Molecules Linked to CancersNIAID; St. Jude's; St. Andrews: Advance in Tackling Common Viral Respiratory DiseaseStructure of Respiratory Virus Yields Clues for Drug DesignStructural Bioinformatics Patents NMR 3-D Structure TechnologyStructural Bioinformatics Patents NMR 3-D Structure TechnologyProteomics: Promising Research/Potential Applications/and New Developments (Technical Insights), Bioinformatics and Computational ProteomicsBioinformatics and Computational ProteomicsBioinformatics and Computational ProteomicsIncyte GenomicsIncyte GenomicsWith Oxford GlycoSciences: Protein Profiles of Health and DiseaseGenicon Sciences: Measuring Minute Protein LevelsWith IBM: Genomics Knowledge Platform Allows Integration of Genomic; Proteomic DataWith Galapagos: Overexpression of Human Genes in AdenovirusConflict with Gene Logic; AffymetrixTurbogenomics: Turbo-Charged Blast Sequence ComparisonTurbogenomics: Turbo-Charged Blast Sequence ComparisonCelera Genomics: Now ProteomicsCelera Moves into Billion-Dollar Proteomics ProgramCelera; Compaq; DOE Build Big SupercomputerEntigen Provides Services to Smaller Research GroupsEntigen Provides Services to Smaller Research GroupsGeneData AG: Collaboration Targets AntibacterialsGeneData AG: Collaboration Targets AntibacterialsAlphagene Identifies 264 New GenesAlphagene Identifies 264 New GenesLion Bioscience Provides System to Nestle and BayerLion Bioscience Provides System to Nestle and BayerGeneformatics: Protein Structure PredictionSchering-Plough: Drug TargetsNMR Spectroscopy with RutgersProteome and Spotfire: Databases and Analytic SoftwareProteome and Spotfire: Databases and Analytic SoftwareNetgenicsNetgenicsShanghai Genecore: Complicated GenealogyShanghai Genecore: Complicated GenealogyNorwegian Radium Hospital: Mining the BiobibliomeNorwegian Radium Hospital: Mining the BiobibliomeNational Center for Genome Resources: ISYS Integrates Bioinformatics Tools; DatabasesNational Center for Genome Resources: ISYS Integrates Bioinformatics Tools; DatabasesMcGill University Launches Centre for BioinformaticsMcGill University Launches Centre for BioinformaticsCompugen and UCSF: New Chemokine Binds HIV Co-ReceptorsCompugen and UCSF: New Chemokine Binds HIV Co-ReceptorsProteomics: Promising Research/Potential Applications/and New Developments (Technical Insights), More Proteomics Companies and Research GroupsMillennium PharmaceuticalsBayer: Proteomics-Derived Drug CandidatePhase II Clinical Trials Underway for Proteasome Inhibitor in CancerZymoGenetics Runs the Gamut of Protein R&DZymoGenetics Runs the Gamut of Protein R&DSet Free by Novo NorkiskZymogenetics Researchers Discover Novel Protein with Potential Role in PsoriasisProteome Systems: Australians Build Proteomics CapabilitiesProteome Systems: Australians Build Proteomics CapabilitiesGemini Genomics and Large Scale Biology Corp. Isolate 70 Disease ProteinsGemini Genomics and Large Scale Biology Corp. Isolate 70 Disease ProteinsMyriad GeneticsMyriad GeneticsMyriad; Hitachi; Oracle; Friedli Join Forces to Map Human ProteomeSchering AG: TherapeuticsMyriad and CancerMyriad Database: Internet Access by DoubleTwistEos Uses Morphosys Combinatorial Antibody LibraryEos Uses Morphosys Combinatorial Antibody LibraryMitoKor: Alzheimer's DiseaseMitoKor: Alzheimer's DiseaseOxford GlycosciencesOxford GlycosciencesIncyte: Drug Efficacy and SafetyEarly Access to Applied Biosystems' New Spectroscopy SystemPioneer: PlantsPackard: BiochipsSunesis PharmaceuticalsSunesis PharmaceuticalsMorphochem AGMorphochem AGScriptgen Becomes Anadys and ExpandsScriptgen Becomes Anadys and ExpandsFraunhofer Institute Pinpoints Candida Pathogenicity ProteinsFraunhofer Institute Pinpoints Candida Pathogenicity ProteinsGenetrace Systems Acquires Strata BiosciencesGenetrace Systems Acquires Strata BiosciencesAxcell Maps Interactions Of WW Domain ProteinsAxcell Maps Interactions Of WW Domain ProteinsLarge Scale Biology Corp.; Navy; NIH Look for Stem-Cell FactorsLarge Scale Biology Corp.; Navy; NIH Look for Stem-Cell FactorsSyngenta and Myriad: Rice Proteomics May Mean Better Cereal CropsSyngenta and Myriad: Rice Proteomics May Mean Better Cereal CropsCiphergen Biosystems: BiomarkersCiphergen Biosystems: BiomarkersBeyond Proteomics: GlycomicsBeyond Proteomics: GlycomicsGlycomindsGlygen Develops Glycoconjugates For Gene TherapyUPenn Scientists Show How Chaperonins Catch Protein-Folding ErrorsUPenn Scientists Show How Chaperonins Catch Protein-Folding ErrorsNewcastle University: Fragments of Dinosaur Protein can Survive in Bone FossilsNewcastle University: Fragments of Dinosaur Protein can Survive in Bone FossilsScripps: Expanding E. Coli's Amino Acid Repertoire Paves Way for Engineered ProteinsScripps: Expanding E. Coli's Amino Acid Repertoire Paves Way for Engineered ProteinsGladstone Institute; UCSF: HIV Viral Protein Plays Offense and Defense Against Immune SystemGladstone Institute; UCSF: HIV Viral Protein Plays Offense and Defense Against Immune SystemUCSD: Protein Responsible for Failing HeartUCSD: Protein Responsible for Failing HeartCeres Pharmaceuticals: Powerful New Vaccines from YeastCeres Pharmaceuticals: Powerful New Vaccines from YeastCellular Signaling Alliance Unites Researchers Via InternetCellular Signaling Alliance Unites Researchers Via InternetUniversity of Illinois: New Mechanism for Cell SignalingUniversity of Illinois: New Mechanism for Cell SignalingNCI Intensifies InformaticsNCI Intensifies InformaticsXenometrix Wins US Gene-Profiling PatentXenometrix Wins US Gene-Profiling PatentPNNL: Top Role in Biological Sciences InitiativePNNL: Top Role in Biological Sciences InitiativeDana-Farber Cancer Institute: Molecular Gateways to DeathDana-Farber Cancer Institute: Molecular Gateways to DeathProteomics: Promising Research/Potential Applications/and New Developments (Technical Insights), Markets and Barriers to CommercializationMarketsMarketsSectors and OpportunitiesSmall Companies Can CompeteInternational CompetitionTechnology FusionSynergy: New Directions/Partnership CollaborationsSoftwareHardwareBioinformaticsOther MarketsBarriers to CommercializationBarriers to CommercializationIntroductionBioinformaticsLabs on Chips (LOCs) and MicroarraysProteomics: Promising Research/Potential Applications/and New Developments (Technical Insights), AppendicesAppendix A: ContactsContactsCouncil Members; Human Proteomics Organization (HUPO)Appendix B: Recent Patents in Proteomics and BioinformaticsGeneral ProteomicsBioinformaticsAppendix C and D: Website URLs and PublicationsWebsite URLsPublications




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