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CGT Research Outlook and Technology Growth Opportunities

Healthcare CGT Research Outlook and Technology Growth Opportunities

CGT Landscape Assessment

INDUSTRY
Healthcare

RELEASE DATE
05-Aug-2024
REGION
Global
DELIVERABLE TYPE
Technology Research

RESEARCH CODE
DAE6-01-00-00-00
SKU
HC_2024_907
Yes
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CGT Research Outlook and Technology Growth Opportunities
Published on: 05-Aug-2024 | SKU: HC_2024_907

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Description

The CGT landscape has evolved extensively over the past decade. More than 80 CGT products have been commercialized globally, with 34 FDA-approved cell and gene therapies in 2023 alone. The rise in product pipelines and clinical success rates has led to the growing demand for the development of new technology platforms, manufacturing capabilities, and expansion to new disease areas.

Over the past five years, the patent landscape, investment landscape, and clinical trial segment have had consistent growth and activity. All three segments contribute extensively to the growth of CGTs and showcase the promising potential of CGTs for the future. The CGT landscape has three main categories of therapies: cell therapies, gene therapies, and gene-modified cell therapies, with all three progressing well over the past years. Gene-modified cell therapies, such as CAR-T and CAR-NK, have a higher number of clinical programs in the pipeline and are expected to have a high clinical impact in the coming years.

CGT developers are exploring new disease areas, apart from hematological conditions and oncology, to include diabetes, cardiovascular diseases, and neurological conditions, which will boost the demand for CGTs.

The report covers the developments and trends in the CGT landscape. A collaborative environment showing the high adoption of new technologies to improve CGTs will transform the end-to-end capabilities in CGT development and manufacturing.

Patent activity is high because of consistent developments in technology for vector design, cell line manufacturing, digitalization of CGT manufacturing capabilities, and AI integration across the end-to-end CGT development. Venture capital firms see huge potential in the CGT segment in the coming years and have been constant supporters in backing start-ups and mid-sized CGT developers to accelerate their pipelines. In the coming years, the number of CGTs receiving regulatory approvals is predicted to multiply by three fold, and policies will be put in place to increase patient accessibility.

Infographic
Table of Contents

Why Is It Increasingly Difficult to Grow?

The Strategic Imperative 8™

The Impact of the Top 3 Strategic Imperatives on the Cell and Gene Therapy Industry

Growth Opportunities Fuel the Growth Pipeline Engine™

Research Methodology

Scope of Analysis

Segmentation

Growth Drivers

Growth Restraints

Macro to Micro Visioning and Implications

Snapshot of CGT Development

Global Growth of CGT Approvals

CGT R&D Outlook

Manufacturing Expansion: Catalysts for CGT Manufacturing

CGT—Overall Patent Trends

IP Landscape Gene-modified Cell Therapies

Top Patent Applicants in Gene-modified Cell Therapies

IP Landscape—Gene Therapies

Top Patent Applicants in Gene Therapies

IP Landscape Stem Cell Therapies

Top Patent Applicants in Stem Cell Therapies

An Overview of the Patent Landscape in CGTs

Investment Trends in the CGT Landscape

Investment Trends in the CGT Expansion of Manufacturing Units

Investments in CGT Technology Platforms

Continued Investments to Accelerate Clinical Trials

Growing Mergers and Acquisitions

Early-stage CGT Investment Trends by Venture Capitalists

GV, United States

SAMSARA BIOCAPITAL, United States

ARCH VENTURE PARTNERS, United States

OrbiMed, United States

ALEXANDRIA, United States

RA CAPITAL, United States

Publication Trends in CGT

Recent Initiatives and Research Accelerators Driving Innovations

Global Trends in CGT R&D

Emerging Technology Areas in CGT Development

Choice of Vector Depends on Indication and Transgene Expression

Engineering Viral Vectors to Improve Safety and Functionality

Innovations in Vector Engineering

Growing Shift from Autologous to Allogeneic Cell Therapies

Emerging Technology Trends for CGT Manufacturing

Shift toward Factory of the Future for CGT Manufacturing

Notable Recent Collaborations between CGT Platforms and Biopharma Companies to Accelerate CGT Development

Clinical Pipeline Development of Gene Therapies

Clinical Development of Gene-modified Cell Therapies

Clinical Pipeline Development of Stem Cell Therapies

Growth Opportunity 1: Capacity and Capability Expansion for CDMOs

Growth Opportunity 1: Capacity and Capability Expansion for CDMOs (continued)

Growth Opportunity 2: Technology Licensing Partnerships

Growth Opportunity 2: Technology Licensing Partnerships

Growth Opportunity 3: Shift Towards CGT Development for Chronic Diseases

Growth Opportunity 3: Shift Towards CGT Development for Chronic Diseases (continued)

Technology Readiness Levels (TRL): Explanation

Benefits and Impacts of Growth Opportunities

Next Steps

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The CGT landscape has evolved extensively over the past decade. More than 80 CGT products have been commercialized globally, with 34 FDA-approved cell and gene therapies in 2023 alone. The rise in product pipelines and clinical success rates has led to the growing demand for the development of new technology platforms, manufacturing capabilities, and expansion to new disease areas. Over the past five years, the patent landscape, investment landscape, and clinical trial segment have had consistent growth and activity. All three segments contribute extensively to the growth of CGTs and showcase the promising potential of CGTs for the future. The CGT landscape has three main categories of therapies: cell therapies, gene therapies, and gene-modified cell therapies, with all three progressing well over the past years. Gene-modified cell therapies, such as CAR-T and CAR-NK, have a higher number of clinical programs in the pipeline and are expected to have a high clinical impact in the coming years. CGT developers are exploring new disease areas, apart from hematological conditions and oncology, to include diabetes, cardiovascular diseases, and neurological conditions, which will boost the demand for CGTs. The report covers the developments and trends in the CGT landscape. A collaborative environment showing the high adoption of new technologies to improve CGTs will transform the end-to-end capabilities in CGT development and manufacturing. Patent activity is high because of consistent developments in technology for vector design, cell line manufacturing, digitalization of CGT manufacturing capabilities, and AI integration across the end-to-end CGT development. Venture capital firms see huge potential in the CGT segment in the coming years and have been constant supporters in backing start-ups and mid-sized CGT developers to accelerate their pipelines. In the coming years, the number of CGTs receiving regulatory approvals is predicted to multiply by three fold, and policies will be put in place to increase patient accessibility.
More Information
Deliverable Type Technology Research
Author Neeraja Vettekudath
Industries Healthcare
No Index No
Is Prebook No
Keyword 1 Cgt Research
Keyword 2 Cell And Gene Therapy Market
Keyword 3 Cgt Research
Podcast No
Predecessor DA7F-01-00-00-00
WIP Number DAE6-01-00-00-00